HDL Cholesterol: Hdl cholesterol definition - cholesterol information produced by. How to increase your hdl levels

HDL Cholesterol: Hdl cholesterol definition - cholesterol information produced by. How to increase your hdl levels

Hdl - the quiet cholesterol?. Raising low high-density lipoprotein (hdl) cholesterol.

Ent study has suggested that one form of synthetic HDL cholesterol can actually halt or even reverse coronary artery disease. ( Read about this "plaque dissolver" here.) Unfortunately, currently available drug therapy for increasing HDL levels are only modestly useful, at best. ( Read how to increase your HDL levels here.) What HDL "solutions" are coming? The good news is that big pharma (and their very smart researchers) have recognized that the company that figures out how to increase HDL with minimal side effects wins. And major efforts are being made to develop such drugs. Among these are the cholesteryl ester transfer protein (CETP) inhibiting drugs. CETP is a "bad" molecule that, among other things, moves cholesterol from the HDL form to the LDL form. Inhibiting this molecule is, therefore, a promising approach to increasing HDL cholesterol levels. Pfizer's CETP inhibitor (a drug called torcetrapib) has looked very promising in early trials, and a major phase 3 trial (the kind of trial the FDA considers when deciding whether a new drug can be marketed) should be yielding results in 2006. Several other companies have CETP inhibitors in the pipeline. One company (Avant Pharmaceuticals) is even developing an anti-CETP vaccine. The PPAR drugs (peroxisome proliferation activated receptor agonists) are another class of drugs being studied to raise HDL levels, that work by stimulating a pro-HDL gene. Several companies are working on PPAR compounds, but research is not as far along as for the CETP drugs. A very interesting line of research is wit

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Hdl (high-density lipoprotein) cholesterol.

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2007-02-02 11:48:51

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